Drugs commonly administered by iv infusion in the ICU

AMINOPHYLLINE (250 mg ampl)

       Loading Dose: 5 - 6 mg/kg (in 20 min)
   Maintenance Dose: 0.2 - 0.9 mg/kg.h
           Dilution: 1 g/250 ml D5W
Final Concentration: 4 mg/ml

Comments:Climetidine slows metabolism; serum levels 10-20 ug/ml; major side effects: tachycardia, tachyarrhythmias, nausea, and vomiting; seizures with serum levels >30 ug/ml

BIBLIOGRAPHY

1. Hung SN, Jusko WJ, Yurnchak AM: Effect of smoking on theophylline disposition. Clin Pharmacol Ther 1976; 19:546
2. Chakrin LW, Krell D: Pathophysiology and pharmacotherapy of asthma: An overview. J Pharm Sci 1980; 69:236
3. Nakada T, Kwee IL, Lerner Am, et al: Theophylline induced seizures; Clinical and pathophysiological aspects. West J Med 1983; 138:371
4. Slugg PH, Pippenher CE: Theophylline and its interactions Cleve Clin Q 1985:1985; 52:417

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This page last updated 11/04/00